Mesothelioma TreatmentChemotherapy
Carboplatin (paraplatin)
Used widely in the treatment of both ovarian and lung cancer, the drug known as carboplatin is sometimes used to treat patients suffering from mesothelioma. Manufactured by Bristol Myers Squibb, carboplatin is generally prescribed in conjunction with another chemo drug, gemcitabine.
Carboplatin has been on the market for almost two decades. It is known in the medical world as a DNA alkylating agent, and those who are prescribed the drug report far fewer side effects than with its parent compound, cisplatin (often used with Alimta). Researchers claim that the lack of uncomfortable side effects is due to the added stability of carboplatin in the bloodstream, which in turn prevents proteins from binging to it, allowing it to remain in the body for longer periods of time. Adversely, it takes much larger doses for carboplatin to be as effective as cisplatin in fighting cancer cells.
How is it Administered?
- Carboplatin is a clear liquid that may be given intravenously, as is the case with many chemotherapy drugs.
- The drug can also be administered through a central line inserted near the patients collarbone or in the crook of the arm.
Possible Side Effects of Carboplatin
The most serious side effect of carboplatin is the reduction in production of white blood cells and platelets. This shortage may cause an increased chance of infection and difficulty clotting. Your doctor will stress that its important to avoid any who is sick while youre taking this drug.
- Nausea and/or vomiting
- Anemia
- Tiredness/weakness
- Loss of appetitite
- Diarrhea
- Tinnitus (ringing in the ear) most commonly associated with high doses
- Hair loss (especially when dosage is high)
- Changes in taste or soar mouth
- Numbness or tingling in hands and feet
